Fumarate hydratase inhibitor 1
Fumarate hydratase-IN-1
CAS: 1644060-37-6
Molecular Formula: C27H30N2O4
Fumarate hydratase inhibitor 1 - Names and Identifiers
| Name | Fumarate hydratase-IN-1 |
| Synonyms | Fumarate hydratase-IN-1 Fumarate hydratase inhibitor 1 ethyl (3S,3~{a}R)-3-[2-(methylamino)-2-oxoethyl]-2-oxo-1-[(4-phenylphenyl)methyl]-3,4,5,6-tetrahydroindole-3~{a}-carboxylate 3aH-Indole-3a-carboxylic acid, 1-([1,1'-biphenyl]-4-ylmethyl)-1,2,3,4,5,6-hexahydro-3-[2-(methylamino)-2-oxoethyl]-2-oxo-, ethyl ester, (3R,3aS)-rel- |
| CAS | 1644060-37-6 |
Fumarate hydratase inhibitor 1 - Physico-chemical Properties
| Molecular Formula | C27H30N2O4 |
| Molar Mass | 446.54 |
| Density | 1.23±0.1 g/cm3(Predicted) |
| Boling Point | 693.0±55.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 15.97±0.46(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Fumarate hydratase-IN-1 inhibits SW620, ACHN, HCT-116, PC3, and SK-MEL-28 cell lines with a mean IC 50 of 2.2 μM. |
Fumarate hydratase inhibitor 1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.239 ml | 11.197 ml | 22.395 ml |
| 5 mM | 0.448 ml | 2.239 ml | 4.479 ml |
| 10 mM | 0.224 ml | 1.12 ml | 2.239 ml |
| 5 mM | 0.045 ml | 0.224 ml | 0.448 ml |
Last Update：2024-01-02 23:10:35
Fumarate hydratase inhibitor 1 - Reference Information
| biological activity | Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 had anti-proliferative activity against several cell lines with a mean IC50 of 2.2 μm. |
| Target | Fumarate hydratase |
Last Update：2024-04-10 22:29:15
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View History
Fumarate hydratase inhibitor 1
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25987-06-8
317319-34-9
368866-07-3
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3-Fluoro-4-methylanisole
5-Nitro-2-aminophenol
168286-10-0
25987-06-8
317319-34-9
368866-07-3
3279-90-1
915280-81-8
Einecs 309-134-7